Syk Inhibitor II hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

脾酪氨酸激酶 (Syk) 信号传导的影响在狼疮中可能很突出，因为 (i) Syk 是循环免疫复合物、LPS 和 (1→3)-β-D-葡聚糖 (BG) 之间共享的下游信号传导分子，并且(ii) 所有这些因子均可在患有败血症的 Fc γ 受体 IIb 缺陷 (FcgRIIb-/-) 小鼠的血清中检测到。 Syk 抑制下调了 BG + LPS 激活的 FcgRIIb-/- 巨噬细胞中的多种炎症途径，表明 Syk 抑制剂在狼疮中具有潜在的抗炎作用。

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines.

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Others

Other Targets

Chk1

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2490508-82-0

376.77

C14H16ClF3N6O

>98% (HPLC)

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O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years